The geomorphological morphology was analyzed quantificationally and the geomorphological regionalization was studied detailedly based on Digital Elevation Model (DEM) of Hoh Xil area combinated with platform of Geographic Information System (GIS). Research suggests that the Hoh Xil area composes of three types in terms of absolute altitude: the middle, the high and the highest, and the high altitude type makes up about 69.38%. Due to the formation of planation surface, the relief amplitude in this area is less than 200 m mainly included plain, tableland and hill. Rivers headward erosion caused by strong uplift of Qinghai-Tibet plateau was not exert an influence on the Hoh Xil except Sanjiangyuan region. So the primary compose of slope type are micro slope, slow slope and slope which all less than 15°. According to regional differentiation of the essential geomorphological types and their genesis, the Hoh Xil is divided into four major geomorphological regions: the Qiangtang plateau (Region Ⅰ), the east Kunlun mountains (Region Ⅱ), Sanjiangyuan hill mountains (Region Ⅲ) and Qaidam plateau and basins (Region Ⅳ). Moreover, the Region Ⅰ is divided into Hoh Xil plateau lake basin (SubregionⅠ₁) and Dangla high mountains (SubregionⅠ₂). The Region Ⅱ is divided into southern highest mountain (Subregion Ⅱ₁) and northern high mountains (Subregion Ⅱ₂). The morphology research which reflect altitude, relief and slope and regionalization research which show geomorphological pattern and horizontal differentiation of plateau, mountain land, mountain plateau and basin will be of great significance in geomorphic, landform type and exploitation, protection in Hoh Xil.